Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study

Mirjam Kaestli, I Cockburn, Alfred Cortes, Kay Baea, J Rowe, Hans-Peter Beck

    Research output: Contribution to journalArticle

    Abstract

    Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a major pathogenicity factor in falciparum malaria that mediates cytoadherence. PfEMP1 is encoded by ?60 var genes per haploid genome. Most var genes are grouped into 3 subgroups: A, B, and C. Evidence is emerging that the specific expression of these subgroups has clinical significance. Using field samples from children from Papua New Guinea with severe, mild, and asymptomatic malaria, we compared proportions of transcripts of var groups, as determined by quantitative polymerase chain reaction. We found a significantly higher proportion of var group B transcripts in children with clinical malaria (mild and severe), whereas a large proportion of var group C transcripts was found in asymptomatic children. These data from naturally infected children clearly show that major differences exist in var gene expression between parasites causing clinical disease and those causing asymptomatic infections. Furthermore, parasites forming rosettes showed a significant up-regulation of var group A transcripts. � 2006 by the Infectious Diseases Society of America. All rights reserved.
    Original languageEnglish
    Pages (from-to)1567-1574
    Number of pages8
    JournalJournal of Infectious Diseases
    Volume193
    Issue number11
    Publication statusPublished - 2006

    Fingerprint Dive into the research topics of 'Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study'. Together they form a unique fingerprint.

  • Cite this