When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling

Sadid F. Khan; Thornton MacAuley; Steven Y.C. Tong; Ouli Xie; Carly Hughes; Nicholas D.P. Hall; Siddhartha Mahanty; Ian Jennens; Alan C. Street

doi:10.1093/ofid/ofz324

When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling

Sadid F. Khan, Thornton MacAuley, Steven Y.C. Tong, Ouli Xie, Carly Hughes, Nicholas D.P. Hall, Siddhartha Mahanty, Ian Jennens, Alan C. Street

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Abstract

The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular-lumbar composition gradients and putative pathophysiological mechanisms and highlight clinical clues for clinicians.

Original language	English
Article number	ofz324
Pages (from-to)	1-4
Number of pages	4
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	7
DOIs	https://doi.org/10.1093/ofid/ofz324
Publication status	Published - Jul 2019

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10.1093/ofid/ofz324Licence: CC BY-NC-ND

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title = "When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling",

abstract = "The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular-lumbar composition gradients and putative pathophysiological mechanisms and highlight clinical clues for clinicians.",

keywords = "cerebrospinal fluid, cryptococcal meningitis, lumbar puncture, meningitis, tuberculous meningitis",

author = "Khan, {Sadid F.} and Thornton MacAuley and Tong, {Steven Y.C.} and Ouli Xie and Carly Hughes and Hall, {Nicholas D.P.} and Siddhartha Mahanty and Ian Jennens and Street, {Alan C.}",

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T2 - Basal Meningitis and the Importance of Lumbar Puncture Sampling

AU - Khan, Sadid F.

AU - MacAuley, Thornton

AU - Tong, Steven Y.C.

AU - Xie, Ouli

AU - Hughes, Carly

AU - Hall, Nicholas D.P.

AU - Mahanty, Siddhartha

AU - Jennens, Ian

AU - Street, Alan C.

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N2 - The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular-lumbar composition gradients and putative pathophysiological mechanisms and highlight clinical clues for clinicians.

AB - The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular-lumbar composition gradients and putative pathophysiological mechanisms and highlight clinical clues for clinicians.

KW - cerebrospinal fluid

KW - cryptococcal meningitis

KW - lumbar puncture

KW - meningitis

KW - tuberculous meningitis

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U2 - 10.1093/ofid/ofz324

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JF - Open Forum Infectious Diseases

SN - 2328-8957

IS - 7

M1 - ofz324

ER -

When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling

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