When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling

Sadid F. Khan, Thornton MacAuley, Steven Y.C. Tong, Ouli Xie, Carly Hughes, Nicholas D.P. Hall, Siddhartha Mahanty, Ian Jennens, Alan C. Street

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    Abstract

    The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular-lumbar composition gradients and putative pathophysiological mechanisms and highlight clinical clues for clinicians.

    Original languageEnglish
    Article numberofz324
    Pages (from-to)1-4
    Number of pages4
    JournalOpen Forum Infectious Diseases
    Volume6
    Issue number7
    DOIs
    Publication statusPublished - Jul 2019

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