Whole Genome Sequence Analysis and Population Genomics of Group A Streptococci

Jake A. Lacey, Taylah B. James, Steven Y.C. Tong, Mark R. Davies

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Citations (Scopus)

Abstract

Whole-genome sequencing (WGS) is used to determine the genetic composition of an organism. This fast-moving field is continually evolving through technical advancements and the development of new bioinformatic tools for analyzing genomic data; however, the basic principles and processes for defining and processing high-quality genome sequence information remain unchanged. Here, we introduce some considerations and describe some commonly used bioinformatic steps for processing raw genome sequence data to generate genome assemblies through to understanding basic population genomics.

Original languageEnglish
Title of host publicationGroup A Streptococcus
Subtitle of host publicationMethods and Protocols
EditorsThomas Proft, Jacelyn Loh
PublisherHumana Press
Pages81-111
Number of pages31
ISBN (Electronic)978-1-0716-0467-0
ISBN (Print)978-1-0716-0466-3
DOIs
Publication statusPublished - 2020

Publication series

NameMethods in molecular biology (Clifton, N.J.)
PublisherHumana Press
Volume2136
ISSN (Print)1064-3745

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