Whole Genome Sequence Analysis and Population Genomics of Group A Streptococci

Jake A. Lacey, Taylah B. James, Steven Y.C. Tong, Mark R. Davies

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    Whole-genome sequencing (WGS) is used to determine the genetic composition of an organism. This fast-moving field is continually evolving through technical advancements and the development of new bioinformatic tools for analyzing genomic data; however, the basic principles and processes for defining and processing high-quality genome sequence information remain unchanged. Here, we introduce some considerations and describe some commonly used bioinformatic steps for processing raw genome sequence data to generate genome assemblies through to understanding basic population genomics.

    Original languageEnglish
    Title of host publicationGroup A Streptococcus
    Subtitle of host publicationMethods and Protocols
    EditorsThomas Proft, Jacelyn Loh
    PublisherHumana Press
    Number of pages31
    ISBN (Electronic)978-1-0716-0467-0
    ISBN (Print)978-1-0716-0466-3
    Publication statusPublished - 2020

    Publication series

    NameMethods in molecular biology (Clifton, N.J.)
    PublisherHumana Press
    ISSN (Print)1064-3745


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