Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia

Ella M. Meumann, Nicholas M. Anstey, Bart J. Currie, Kim A. Piera, Robert Baird, Derek S. Sarovich, Joshua S. Davis

    Research output: Contribution to journalArticle

    Abstract

    Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

    Original languageEnglish
    Article number263
    Pages (from-to)1-4
    Number of pages4
    JournalOpen Forum Infectious Diseases
    Volume6
    Issue number7
    DOIs
    Publication statusPublished - Jul 2019

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    Acinetobacter baumannii
    Pneumonia
    Genome
    Recurrence
    Alcohols

    Cite this

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    title = "Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia",
    abstract = "Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10{\%}) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.",
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    Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia. / Meumann, Ella M.; Anstey, Nicholas M.; Currie, Bart J.; Piera, Kim A.; Baird, Robert; Sarovich, Derek S.; Davis, Joshua S.

    In: Open Forum Infectious Diseases, Vol. 6, No. 7, 263, 07.2019, p. 1-4.

    Research output: Contribution to journalArticle

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    T1 - Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia

    AU - Meumann, Ella M.

    AU - Anstey, Nicholas M.

    AU - Currie, Bart J.

    AU - Piera, Kim A.

    AU - Baird, Robert

    AU - Sarovich, Derek S.

    AU - Davis, Joshua S.

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    KW - Acinetobacter baumannii

    KW - Community-Acquired pneumonia

    KW - Recurrence

    KW - Relapse

    KW - Whole-genome sequencing.

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