Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia

Ella M. Meumann, Nicholas M. Anstey, Bart J. Currie, Kim A. Piera, Robert Baird, Derek S. Sarovich, Joshua S. Davis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

Original languageEnglish
Article number263
Pages (from-to)1-4
Number of pages4
JournalOpen Forum Infectious Diseases
Volume6
Issue number7
DOIs
Publication statusPublished - Jul 2019

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Acinetobacter baumannii
Pneumonia
Genome
Recurrence
Alcohols

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title = "Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia",
abstract = "Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10{\%}) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.",
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Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia. / Meumann, Ella M.; Anstey, Nicholas M.; Currie, Bart J.; Piera, Kim A.; Baird, Robert; Sarovich, Derek S.; Davis, Joshua S.

In: Open Forum Infectious Diseases, Vol. 6, No. 7, 263, 07.2019, p. 1-4.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Piera, Kim A.

AU - Baird, Robert

AU - Sarovich, Derek S.

AU - Davis, Joshua S.

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KW - Acinetobacter baumannii

KW - Community-Acquired pneumonia

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