Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia

Ella M. Meumann; Nicholas M. Anstey; Bart J. Currie; Kim A. Piera; Robert Baird; Derek S. Sarovich; Joshua S. Davis

doi:10.1093/ofid/ofz263

Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia

Ella M. Meumann, Nicholas M. Anstey, Bart J. Currie, Kim A. Piera, Robert Baird, Derek S. Sarovich, Joshua S. Davis

Global and Tropical Health

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

Original language	English
Article number	263
Pages (from-to)	1-4
Number of pages	4
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	7
DOIs	https://doi.org/10.1093/ofid/ofz263
Publication status	Published - Jul 2019

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10.1093/ofid/ofz263Licence: CC BY

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title = "Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia",

abstract = "Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.",

keywords = "Acinetobacter baumannii, Community-Acquired pneumonia, Recurrence, Relapse, Whole-genome sequencing.",

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AU - Meumann, Ella M.

AU - Anstey, Nicholas M.

AU - Currie, Bart J.

AU - Piera, Kim A.

AU - Baird, Robert

AU - Sarovich, Derek S.

AU - Davis, Joshua S.

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N2 - Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

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KW - Acinetobacter baumannii

KW - Community-Acquired pneumonia

KW - Recurrence

KW - Relapse

KW - Whole-genome sequencing.

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ER -

Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia

Abstract

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