Whole genome sequencing to investigate a putative outbreak of the virulent community-associated methicillin-resistant Staphylococcus aureus ST93 clone in a remote Indigenous community

Ella Manibarr Meumann, Patiyan Andersson, Fiona Yeaman, Sarah Oldfield, Rachael Anne Lilliebridge, Stephen D. Bentley, Vicki Krause, Miles Beaman, Bart Currie, Deborah Holt, Philip Giffard, Steven Tong

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    Abstract

    We report two cases of severe pneumonia due to clone ST93 methicillin-resistant Staphylococcus aureus (MRSA) presenting from a remote Australian Indigenous community within a 2-week period, and the utilization of whole genome sequences to determine whether these were part of an outbreak. S. aureus was isolated from 12 of 92 nasal swabs collected from 25 community households (including the two index households); one isolate was ST93. Three of five skin lesion S. aureus isolates obtained at the community were ST93. Whole genome sequencing of the ST93 isolates from this study and a further 20 ST93 isolates from the same region suggested that recent transmission and progression to disease had not taken place. The proximity in time and space of the two severe pneumonia cases is probably a reflection of the high burden of disease due to ST93 MRSA in this population where skin infections and household crowding are common.
    Original languageEnglish
    Pages (from-to)1-7
    Number of pages7
    JournalMicrobial Genomics
    Volume2
    Issue number12
    DOIs
    Publication statusPublished - 2016

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    Methicillin-Resistant Staphylococcus aureus
    Disease Outbreaks
    Clone Cells
    Genome
    Staphylococcus aureus
    Pneumonia
    Skin
    Crowding
    Nose
    Disease Progression
    Infection
    Population

    Cite this

    Meumann, Ella Manibarr ; Andersson, Patiyan ; Yeaman, Fiona ; Oldfield, Sarah ; Lilliebridge, Rachael Anne ; Bentley, Stephen D. ; Krause, Vicki ; Beaman, Miles ; Currie, Bart ; Holt, Deborah ; Giffard, Philip ; Tong, Steven. / Whole genome sequencing to investigate a putative outbreak of the virulent community-associated methicillin-resistant Staphylococcus aureus ST93 clone in a remote Indigenous community. In: Microbial Genomics. 2016 ; Vol. 2, No. 12. pp. 1-7.
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    abstract = "We report two cases of severe pneumonia due to clone ST93 methicillin-resistant Staphylococcus aureus (MRSA) presenting from a remote Australian Indigenous community within a 2-week period, and the utilization of whole genome sequences to determine whether these were part of an outbreak. S. aureus was isolated from 12 of 92 nasal swabs collected from 25 community households (including the two index households); one isolate was ST93. Three of five skin lesion S. aureus isolates obtained at the community were ST93. Whole genome sequencing of the ST93 isolates from this study and a further 20 ST93 isolates from the same region suggested that recent transmission and progression to disease had not taken place. The proximity in time and space of the two severe pneumonia cases is probably a reflection of the high burden of disease due to ST93 MRSA in this population where skin infections and household crowding are common.",
    author = "Meumann, {Ella Manibarr} and Patiyan Andersson and Fiona Yeaman and Sarah Oldfield and Lilliebridge, {Rachael Anne} and Bentley, {Stephen D.} and Vicki Krause and Miles Beaman and Bart Currie and Deborah Holt and Philip Giffard and Steven Tong",
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    language = "English",
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    Whole genome sequencing to investigate a putative outbreak of the virulent community-associated methicillin-resistant Staphylococcus aureus ST93 clone in a remote Indigenous community. / Meumann, Ella Manibarr; Andersson, Patiyan; Yeaman, Fiona ; Oldfield, Sarah ; Lilliebridge, Rachael Anne; Bentley, Stephen D.; Krause, Vicki; Beaman, Miles; Currie, Bart; Holt, Deborah; Giffard, Philip; Tong, Steven.

    In: Microbial Genomics, Vol. 2, No. 12, 2016, p. 1-7.

    Research output: Contribution to journalArticleResearchpeer-review

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    AU - Andersson, Patiyan

    AU - Yeaman, Fiona

    AU - Oldfield, Sarah

    AU - Lilliebridge, Rachael Anne

    AU - Bentley, Stephen D.

    AU - Krause, Vicki

    AU - Beaman, Miles

    AU - Currie, Bart

    AU - Holt, Deborah

    AU - Giffard, Philip

    AU - Tong, Steven

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