E-books have increasingly penetrated the academic world. However, despite efforts from Vietnamese universities and colleges to establish and broaden their e-books collection, students seem reluctant to use these digital books. This study aims to examine the barriers to using e-books in libraries among Vietnamese students. Data were obtained from 355 undergraduate students who were interested in e-books. The findings demonstrate that some key barriers impeding students from using e-books include the lack of computers and e-books in libraries, limited information and knowledge about e-books and their preference of using print books. Interestingly, female students tend to perceive the barriers to be stronger than their male counterparts. This study’s findings have important implications for universities, libraries and publishers who seek to promote e-books to students.