ZIF-8 with cationic defects toward efficient 125I2 uptake for in vitro radiotherapy of colon cancer

Xin Xin Tian; Yi Tong Liu; Yan Li; Xin Yu Qiu; Wen Hua Zhang; David J. Young; Qiu Chen

doi:10.1039/d1cc07304d

ZIF-8 with cationic defects toward efficient ¹²⁵I₂ uptake for in vitro radiotherapy of colon cancer

Xin Xin Tian, Yi Tong Liu, Yan Li, Xin Yu Qiu, Wen Hua Zhang, David J. Young, Qiu Chen

CDU College of Engineering, IT and Environment

Research output: Contribution to journal › Article › peer-review

Abstract

Introducing 2,3-dimethyl-1H-imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic ‘missing linker’ defects. ZIF-8 + (38) adsorbs ¹²⁵I₂ and the resulting radioactive host-guest complex exhibits in vitro cytotoxicity comparable to that of Na¹²⁵I against colon cancer cell line CT26.

Original language	English
Pages (from-to)	6942-6945
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	49
DOIs	https://doi.org/10.1039/d1cc07304d
Publication status	Published - 23 May 2022

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title = "ZIF-8 with cationic defects toward efficient 125I2 uptake for in vitro radiotherapy of colon cancer",

abstract = "Introducing 2,3-dimethyl-1H-imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic {\textquoteleft}missing linker{\textquoteright} defects. ZIF-8 + (38) adsorbs 125I2 and the resulting radioactive host-guest complex exhibits in vitro cytotoxicity comparable to that of Na125I against colon cancer cell line CT26.",

author = "Tian, {Xin Xin} and Liu, {Yi Tong} and Yan Li and Qiu, {Xin Yu} and Zhang, {Wen Hua} and Young, {David J.} and Qiu Chen",

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doi = "10.1039/d1cc07304d",

language = "English",

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publisher = "Royal Society of Chemistry (RSC)",

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TY - JOUR

T1 - ZIF-8 with cationic defects toward efficient 125I2 uptake for in vitro radiotherapy of colon cancer

AU - Tian, Xin Xin

AU - Liu, Yi Tong

AU - Li, Yan

AU - Qiu, Xin Yu

AU - Zhang, Wen Hua

AU - Young, David J.

AU - Chen, Qiu

PY - 2022/5/23

Y1 - 2022/5/23

N2 - Introducing 2,3-dimethyl-1H-imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic ‘missing linker’ defects. ZIF-8 + (38) adsorbs 125I2 and the resulting radioactive host-guest complex exhibits in vitro cytotoxicity comparable to that of Na125I against colon cancer cell line CT26.

AB - Introducing 2,3-dimethyl-1H-imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic ‘missing linker’ defects. ZIF-8 + (38) adsorbs 125I2 and the resulting radioactive host-guest complex exhibits in vitro cytotoxicity comparable to that of Na125I against colon cancer cell line CT26.

UR - http://www.scopus.com/inward/record.url?scp=85131872427&partnerID=8YFLogxK

U2 - 10.1039/d1cc07304d

DO - 10.1039/d1cc07304d

M3 - Article

C2 - 35640157

AN - SCOPUS:85131872427

VL - 58

SP - 6942

EP - 6945

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 49

ER -

ZIF-8 with cationic defects toward efficient ¹²⁵I₂ uptake for in vitro radiotherapy of colon cancer

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