Inflammation, oxidative stress and cardiovascular risk factors in Australian Aboriginal people

  • Tomer Shemesh

    Student thesis: Doctor of Philosophy (PhD) - CDU


    C-reactive protein (CRP), semicarbazide-sensitive amine oxidase (SSAO)and the metabolic syndrome (MS) were assessed as risk markers of cardiovascular disease (CVD) in health screenings in remote Aboriginal communities. MS was prevalent among Aboriginal people; obesity was a driver of all MS components, including CRP in women but not in men. however, low HDL-C featured prominently, even in the lean. CRP identified 60% of the population at high CVD-risk and SSAO correlated positively with glucose metabolism, also confirmed in-vitro. Both CRP and SSAO were elevated with the MS. These observations suggested that conventional MS and obesity criteria may require knowledge of CVD end-points to be applicable in the population. SSAO may be useful to identify abnormal glucose metabolism and CRP appears promising as a CVD-risk marker. Further research is required to elucidate the relationship between inflammation, oxidative-stress and abnormal metabolism to curb the burden of CVD in this high CVD-risk population.

    Note: Please note that Appendix 1 is not available online.
    Date of AwardJan 2007
    Original languageEnglish
    SupervisorKerin O'Dea (Supervisor)

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