Inflammation, oxidative stress and cardiovascular risk factors in Australian Aboriginal people

  • Tomer Shemesh

    Student thesis: Doctor of Philosophy (PhD) - CDU

    Abstract

    C-reactive protein (CRP), semicarbazide-sensitive amine oxidase (SSAO)and the metabolic syndrome (MS) were assessed as risk markers of cardiovascular disease (CVD) in health screenings in remote Aboriginal communities. MS was prevalent among Aboriginal people; obesity was a driver of all MS components, including CRP in women but not in men. however, low HDL-C featured prominently, even in the lean. CRP identified 60% of the population at high CVD-risk and SSAO correlated positively with glucose metabolism, also confirmed in-vitro. Both CRP and SSAO were elevated with the MS. These observations suggested that conventional MS and obesity criteria may require knowledge of CVD end-points to be applicable in the population. SSAO may be useful to identify abnormal glucose metabolism and CRP appears promising as a CVD-risk marker. Further research is required to elucidate the relationship between inflammation, oxidative-stress and abnormal metabolism to curb the burden of CVD in this high CVD-risk population.

    Note: Please note that Appendix 1 is not available online.
    Date of AwardJan 2007
    Original languageEnglish
    SupervisorKerin O'Dea (Supervisor)

    Cite this

    Inflammation, oxidative stress and cardiovascular risk factors in Australian Aboriginal people
    Shemesh, T. (Author). Jan 2007

    Student thesis: Doctor of Philosophy (PhD) - CDU